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Pathophysiology of acute pancreatitis : a multistep disease*

Journal Volume 66 - 2003
Issue Fasc.2 - Symposium
Author(s) Jean-Louis Frossard
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Division of Gastroenterology and Hepatology, Geneva University Hospital, Switzerland.

Acute pancreatitis is an inflammatory disease diagno- sed mainly in presence of acute abdominal pain associa- ted with a concomitant rise of serum amylase and lipase levels (1-3). In western countries, gallstone migration into the common bile duct and alcohol abuse account for most of the aetiologies of the disease (4-7). The injury is usually mild in 70 to 80% of cases, but 10-20% of the patients have a severe injury and, among them, 15 to 25% will die (4,8).

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